Laboratory of Chemical Modification of Natural Compounds
WELCOME
To Our Institute Website!
Tbilisi State Medical University I.Kutateladze Institute of Pharmacochemistry

Director's Page

Laboratory of Chemical Modification of Natural Compounds Departments

(Established in 1978)


The department of synthesis of steroidal compounds founded in 1978 in the institute of pharmacochemistry has changed name in 2002 and now is called the laboratory of chemical modification of natural compounds .
The main research Field: Chemical modification of compounds isolated from plant material, intesification of specific activity, decreasing of toxicity and investigation of new activity.
The main results:
• Has been worked out a new method of splitting without autoclave of steroidal sapogenin –tigogen isolated from “Yucca glorisa” growing in Georgia. The initial compound 3β- acetoxi-5α-pregn-16-en-20-on and 3β-hydroxid-5α-androstan-17-on acetate received for synthesis of biologically active 5α-steroidal medicinal drug;
• Have been worked out methods of 3- and 17- aminosteroids, also 2 alternative ways of synthesis 17β-amino-5α-androstan. Have been synthesized some of their derivatives; 
• Dyhydrotestosteron has been synthesized - product of testosteron’s metabolic transformation;
• Have been worked out a new method of synthesis for main component of the medrosteron propionate for anticancer activity drug;
• The new derivates of cetones containing saturated and non saturated steroidal nucleus – hydrazones, oximes, semi- and tiosemicarbozanes have been synthesized;
• Modified steroids and their derivatives have been synthesized;
• The antitubercular, antiviral, antiarythmic, psycotropic and general narcotic avtivity of new steroidal compounds are investigated.
The main results are published in more than 75 acientific articles.
3 author sretificates are issued.

 

Head of Laboratory: PhD N. Nadaraia,
Senior scientis: scientist: PhD M. Kakhabrishvili,

Research scientist: PhD. N. Barbakadze

Laboratory assistant: E.Onashvili

Administration

 

more



Laboratory of Steroids and Cardiac Glycosides

 

 

more



Laboratory of Medicinal Fermentology

more



Laboratory of Phenolic Compounds

 

more



Laboratory of Terpene Compounds

more



Laboratory of Plant Biopolymers

more



Laboratory of Akaliods

more



Laboratory of Lipids and Anthraquinones

more



Laboratory of Pharmaceutical Technology

more



Laboratory of Chemical Analysis and Standardisation

more



Laboratory of Chemical Modification of Natural Compounds

more



Laboratory of Pharmacobotany

more



Department of Pharmacology

more



Pilot Plant

more



Department of the Resource Management

 

more



Department of Scientific Information

 

 

more



Administrative support center


more



Storehouse

more



I.Kutateladze Institute of Pharmacochemistry © Copyright 2009-2014 All rights reserved