Caripazim®- original preparation for the treatment of necrotic wounds and vertebral diseases
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Caripazim®

Caripazim - a mixture of phytogenous protein-degrading enzymes, prepared from proteolytic enzyme latex of papaya. Active components of the medication are: papain, chymopapain A, chymopapain B, peptidase B and mucolytic ferment – lysozyme



 

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Caripazim® - trademark of the medicinal preparation which was originally developed at I.Kutateladze Institute of Pharmacochemistry and is commercially manufactured since 1987. More than 100 000 patients were successfully treated with Caripazym in different countries.

 

Clinical trials carried at lead hospitals, including Moscow Burdenko Institute of Neurosurgery, confirm high efficacy of Caripazim both in surgery  and neurology.

 

Application Instruction
Caripazim®

Caripazim is a mixture of phytogenous protein-degrading enzymes, prepared from proteolytic enzyme latex of papaya. Active components of the medication are: papain, chymopapain A, chymopapain B, peptidase B and mucolytic ferment – lysozyme, containing in its active centres sulfhydryl groups. 
PHARMACOLOGICAL FEATURES:
Caripazim offers wide spectrum of proteolytic action. It destroys sphacelous tissues, dilutes viscous secretion, exudates, blood clots.

THERAPEUTIC INDICATIONS: 

Caripazim is indicated for the treatment of surgical, traumatological – orthopedic, neurosurgical, stomatological practice. Caripazim is used in the Treatment of third degree burn, to interfere with scab formation and clear the granulation tissue of wounds from necrotic suppurative tissue debris; in the Treatment of vertebral osteochondrosis, various types of intervertebral disc hernia or diskogenic radiculitis, post-traumatic flexion contracture of fingers, keloid [cheloid] cicatrix of various etymology, osteoarthritis of large joints, scapulohumeral periarthritis, cerebral (including optochiazmolic) and vertebral arachnoiditis, neuritis of the facial nerve, tunnel syndromes; in stomatology: periodontitis, pulpitis, gingivitis, paradontosis, thrush and ulcer necrotic stomatitis.

DOSAGE AND DIRECTIONS FOR USE:
Caripazim is administered locally in the treatment of burn wound infections, as solutions with concentrations 17.5PU/ml, 35 PU/ml, 70 PU/ml depending upon scab thickness. Solution is to be prepared immediately before usage, dissolved in 0.5% aqueous solution of novocaine or natrium chloride isotonic solution. Absorbent paper wetted with the said solution is put on the burn surface area, and then covered by moistureproof bandage. Simultaneously solution is applied to 30% of the body area. Bandage is changed daily or twice a day, removing loose distal necrotic tissues. Treatment cours lasts for 4-12 days.
For the treatment of the abovementioned pathologies of musculoskeletal [locomotor] system: keloid [cheloid] cicatrix, neuritis and so on, Caripazim is administered using electrophoretic method. 
In stomatology Caripazim is applied to wash tooth root channels with Caripazim solution. Contents of a bottle is dissolved in 5-10 ml distilled water or physiological solution. For the treatment of chronic Periodontitis washing tooth root channels and in-channel electrophoresis is applied (3-5 sessions) with 1-2% Caripazim solution and wetted tampon is left for 3-4 days. For the treatment of Gingivitis, Paradontosis, traumatic erosion and ulcers Caripazim application is applied for 15-20 minutes (4-10 procedures). 
The Medication is used for in-patient and out-patient treatment.
SIDE EFFECTS AND SPECIAL PRECAUTIONS:
Caripazim may cause an allergic reaction. Antihistamine therapy is given (diazolin, tavegyl and others, locally applying hydrocortisone ointment or cream “Linia”) in case of hypersensitivity expressed in the form of itching activities and increased temperature.
CONTRAINDICATION:
Should not be applied subcutaneously, intramuscularly or intravenously; in acute inflammation, sequestration of disk hernia and severe foraminal disc sequestration.
PRESENTATION:
350 PU, botlles, sterile frozen-dried preparation.
STORAGE INSTRUCTIONS:
Store at a dry place at +2 + 8°C; protect from light. 

 

  

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